diff --git a/src/wp-admin/includes/plugin.php b/src/wp-admin/includes/plugin.php
index fae10f1a679a4..46be6f610c447 100644
--- a/src/wp-admin/includes/plugin.php
+++ b/src/wp-admin/includes/plugin.php
@@ -1054,6 +1054,9 @@ function delete_plugins( $plugins, $deprecated = '' ) {
 		return new WP_Error( 'could_not_remove_plugin', sprintf( $message, implode( ', ', $errors ) ) );
 	}
 
+	// Force refresh of plugin update information.
+	wp_clean_plugins_cache();
+
 	return true;
 }
 
diff --git a/tests/phpunit/tests/ajax/wpAjaxDeletePlugin.php b/tests/phpunit/tests/ajax/wpAjaxDeletePlugin.php
index 1fc3d9422d85b..35c8aad217d95 100644
--- a/tests/phpunit/tests/ajax/wpAjaxDeletePlugin.php
+++ b/tests/phpunit/tests/ajax/wpAjaxDeletePlugin.php
@@ -131,6 +131,8 @@ public function test_invalid_file() {
 	 * @group ms-excluded
 	 *
 	 * @covers ::delete_plugins
+	 *
+	 * @ticket 64568
 	 */
 	public function test_delete_plugin() {
 		$this->_setRole( 'administrator' );
@@ -139,6 +141,17 @@ public function test_delete_plugin() {
 		$_POST['plugin']      = 'foo.php';
 		$_POST['slug']        = 'foo';
 
+		// Adds the plugin cache.
+		$plugins_cache = array(
+			'' => array(
+				'foo.php' => array(
+					'Name'    => 'Foo Plugin',
+					'Version' => '1.0',
+				),
+			),
+		);
+		wp_cache_set( 'plugins', $plugins_cache, 'plugins' );
+
 		// Make the request.
 		try {
 			$this->_handleAjax( 'delete-plugin' );
@@ -160,5 +173,8 @@ public function test_delete_plugin() {
 		);
 
 		$this->assertSameSets( $expected, $response );
+
+		// Verify that wp_clean_plugins_cache() was called and cleared both cache and transient.
+		$this->assertFalse( wp_cache_get( 'plugins', 'plugins' ), 'Plugins cache should be cleared after delete_plugins()' );
 	}
 }