diff --git a/src/libraries/Common/src/System/Number.Parsing.Common.cs b/src/libraries/Common/src/System/Number.Parsing.Common.cs
index e43cbe14c29226..96661652f59ef7 100644
--- a/src/libraries/Common/src/System/Number.Parsing.Common.cs
+++ b/src/libraries/Common/src/System/Number.Parsing.Common.cs
@@ -319,6 +319,9 @@ internal enum ParsingStatus
 
         private static bool IsSpaceReplacingChar(uint c) => (c == '\u00a0') || (c == '\u202f');
 
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        private static uint NormalizeSpaceReplacingChar(uint c) => IsSpaceReplacingChar(c) ? '\u0020' : c;
+
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         private static unsafe TChar* MatchNegativeSignChars<TChar>(TChar* p, TChar* pEnd, NumberFormatInfo info)
             where TChar : unmanaged, IUtfChar<TChar>
@@ -345,14 +348,16 @@ internal enum ParsingStatus
                 if (TChar.CastToUInt32(*str) != '\0')
                 {
                     // We only hurt the failure case
-                    // This fix is for French or Kazakh cultures. Since a user cannot type 0xA0 or 0x202F as a
-                    // space character we use 0x20 space character instead to mean the same.
+                    // This fix is for cultures that use NBSP (U+00A0) or narrow NBSP (U+202F) as group/decimal separators
+                    // (e.g., French, Kazakh, Ukrainian). Since a user cannot easily type these characters,
+                    // we accept regular space (U+0020) as equivalent.
+                    // We also need to handle the reverse case where the input has NBSP and the format string has space.
                     while (true)
                     {
                         uint cp = (p < pEnd) ? TChar.CastToUInt32(*p) : '\0';
                         uint val = TChar.CastToUInt32(*str);
 
-                        if ((cp != val) && !(IsSpaceReplacingChar(val) && (cp == '\u0020')))
+                        if (cp != val && NormalizeSpaceReplacingChar(cp) != NormalizeSpaceReplacingChar(val))
                         {
                             break;
                         }
diff --git a/src/libraries/System.Runtime.Numerics/tests/BigInteger/parse.cs b/src/libraries/System.Runtime.Numerics/tests/BigInteger/parse.cs
index bdfde88395a326..4f682c5216e7e9 100644
--- a/src/libraries/System.Runtime.Numerics/tests/BigInteger/parse.cs
+++ b/src/libraries/System.Runtime.Numerics/tests/BigInteger/parse.cs
@@ -1331,6 +1331,31 @@ private static void Eval(BigInteger x, string expected)
             }
             Assert.Equal(expected, actual);
         }
+
+        [Fact]
+        public static void ParseWithNBSPAsGroupSeparator()
+        {
+            // Culture has NBSP as group separator; input has regular spaces.
+            // Exercises MatchChars path: cp=='\u0020' && IsSpaceReplacingChar(val=='\u00A0')
+            CultureInfo nbspCulture = new CultureInfo("en-US");
+            nbspCulture.NumberFormat.NumberGroupSeparator = "\u00A0";
+
+            BigInteger result = BigInteger.Parse("1 234 567", NumberStyles.AllowThousands, nbspCulture);
+            Assert.Equal((BigInteger)1234567, result);
+
+            // Culture has regular space as group separator; input has NBSP.
+            // Exercises MatchChars path: val=='\u0020' && IsSpaceReplacingChar(cp=='\u00A0')
+            CultureInfo spaceCulture = new CultureInfo("en-US");
+            spaceCulture.NumberFormat.NumberGroupSeparator = " ";
+
+            result = BigInteger.Parse("1\u00A0234\u00A0567", NumberStyles.AllowThousands, spaceCulture);
+            Assert.Equal((BigInteger)1234567, result);
+
+            // Culture has regular space as group separator; input has narrow NBSP (U+202F).
+            // Exercises IsSpaceReplacingChar matching U+202F against U+0020
+            result = BigInteger.Parse("1\u202F234\u202F567", NumberStyles.AllowThousands, spaceCulture);
+            Assert.Equal((BigInteger)1234567, result);
+        }
     }
 
     [Collection(nameof(DisableParallelization))]