diff --git a/rules-tests/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector/Fixture/skip_already_filled.php.inc b/rules-tests/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector/Fixture/skip_already_filled.php.inc
new file mode 100644
index 00000000..4f0cb435
--- /dev/null
+++ b/rules-tests/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector/Fixture/skip_already_filled.php.inc
@@ -0,0 +1,15 @@
+<?php
+
+namespace Rector\PHPUnit\Tests\PHPUnit120\Rector\MethodCall\ExplicitMockExpectsCallRector\Fixture;
+
+use PHPUnit\Framework\TestCase;
+
+final class SkipAlreadyFilled extends TestCase
+{
+    public function testMethod(): void
+    {
+        $someClass = $this->createMock(\stdClass::class);
+
+        $someClass->expects($this->once())->method('some');
+    }
+}
diff --git a/rules-tests/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector/Fixture/skip_setup_as_can_be_any.php.inc b/rules-tests/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector/Fixture/skip_setup_as_can_be_any.php.inc
new file mode 100644
index 00000000..c2aee4ef
--- /dev/null
+++ b/rules-tests/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector/Fixture/skip_setup_as_can_be_any.php.inc
@@ -0,0 +1,15 @@
+<?php
+
+namespace Rector\PHPUnit\Tests\PHPUnit120\Rector\MethodCall\ExplicitMockExpectsCallRector\Fixture;
+
+use PHPUnit\Framework\TestCase;
+
+final class SkipSetupAsCanBeAny extends TestCase
+{
+    protected function setUp(): void
+    {
+        $someClass = $this->createMock(\stdClass::class);
+
+        $someClass->method('some');
+    }
+}
diff --git a/rules/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector.php b/rules/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector.php
index 6133cf80..7ae04e76 100644
--- a/rules/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector.php
+++ b/rules/PHPUnit120/Rector/MethodCall/ExplicitMockExpectsCallRector.php
@@ -10,9 +10,11 @@
 use PhpParser\Node\Expr\PropertyFetch;
 use PhpParser\Node\Expr\Variable;
 use PHPStan\Type\ObjectType;
+use Rector\PHPStan\ScopeFetcher;
 use Rector\PHPUnit\Enum\PHPUnitClassName;
 use Rector\PHPUnit\NodeAnalyzer\TestsNodeAnalyzer;
 use Rector\Rector\AbstractRector;
+use Rector\ValueObject\MethodName;
 use Symplify\RuleDocGenerator\ValueObject\CodeSample\CodeSample;
 use Symplify\RuleDocGenerator\ValueObject\RuleDefinition;
 
@@ -80,6 +82,11 @@ public function refactor(Node $node): Node|null
             return null;
         }
 
+        $scope = ScopeFetcher::fetch($node);
+        if ($scope->getFunctionName() === MethodName::SET_UP) {
+            return null;
+        }
+
         if (! $node->var instanceof Variable && ! $node->var instanceof PropertyFetch) {
             return null;
         }